Punjani N, Wald G, Gaffney CD, et al. - The present study was conducted to explore predictors of varicocele-associated pain and whether it predicts semen parameters after microsurgical varicocelectomy. Researchers evaluated all men diagnosed with a varicocele by two surgeons from 2017 to 2020, excluding those who did not undergo surgical treatment. They used logistic regression models to evaluate predictors of pain. The study enrolled a total of 313 men, with relatively similar proportions completed by both surgeons (48.2% and 51.8%). The findings suggested that almost 1/3 of men presented with varicocele-associated pain. The outcomes reveal that pain does not predict response to varicocelectomy, but these men tend to be younger, and have higher grade varicoceles.