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Predictors of surgical treatment burden, outcomes and overall survival in older adults with basal cell carcinoma: Results from the prospective, multicenter BATOA cohort

Journal of the American Academy of Dermatology Jun 04, 2021

van Winden MEC, Bronkhorst EM, Visch MB, et al. - Researchers used data from the prospective multicenter BATOA (“BAsal cell carcinoma Treatment in Older Adults”) cohort study, to assess as well as determine predictors for treatment burden, treatment results and overall survival in patients ≥70 years, surgically managed for basal cell carcinoma (BCC) in the head-and-neck area. This analysis involved 539 patients (median age: 78 years). A low overall treatment burden (median 8.6) as well as good cosmetic outcome was observed among patients. Instrumental activities of daily living (iADL) dependency, female gender, complications, tumor diameter, and polypharmacy were revealed as factors predictive of higher treatment burden. Within follow-up, deaths of 35 (6.5%) patients were reported, and increasing comorbidity index and iADL dependency were identified as predictors for mortality. Post-correction for covariates, these outcomes did not differ between Mohs micrographic surgery and conventional excision. Age was not significantly related to any outcome. In the light of these data, experts recommend avoiding BCC management decisions on the basis of chronological age alone, whereas they advise to pay more attention to patient-related factors. Findings demonstrate usefulness of early BCC intervention for robust and fit patients or those having symptoms.

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