Pelliccia F, Pasceri V, Niccoli G, et al. - A total of 44 studies comprising 36,932 individuals (20,052 women and 16,880 men) were involved in order to ascertain the long-term mortality of individuals with myocardial infarction and nonobstructed coronary arteries (MINOCA) and to recognize possible prognostic determinants of long-term outcome. Overall, with important heterogeneity, the annual mortality rate was 2.0%. In a meta-analysis of the 26 studies, annual rates of long-term total mortality were 2.2% and 5.0%, respectively, were exhibited on contrasting individuals with MINOCA and myocardial infarction and obstructive coronary artery disease, with a notable variation between the two groups. Through a meta-regression analysis, it as exhibited that normal ejection fraction and normal coronary arteries at angiography were inversely associated with long-term mortality, while during follow-up and ST depression on the admission electrocardiogram, the use of beta-blockers was undeviatingly correlated with worse outcome. Hence, the long-term mortality is lower following MINOCA vs patients with myocardial infarction and obstructive coronary artery disease, however, it is not insignificant. Moreover, important predictors of long-term prognosis are decreased ejection fraction, nonobstructive coronary artery disease, use of beta-blockers during follow up and ST depression on the admission electrocardiogram.