Moran O, et al. - Among women (including 97 premenopausal and 59 postmenopausal, age range: 27-68 years) with a strong family history of breast cancer but no BRCA1 or BRCA2 mutation, researchers assessed the link between reproductive, hormonal, and lifestyle risk factors and mammographic density. A mean percentage density of 28.8% vs 41.6% was seen in premenopausal women who had two live births vs those who had one live birth, respectively. Among premenopausal and postmenopausal women, a lower mean percentage density was found in women with a high body weight vs those with a low body weight. A lower mean dense area was observed among premenopausal women who smoked for 14 years or longer vs those premenopausal women who smoked for a shorter duration. Among postmenopausal women, a higher mean percentage density and dense area were observed in former smokers vs never smokers. The statistical significance of the link between body weight and percentage density among premenopausal women was preserved after applying the Bonferroni correction. Based on these findings, risk prediction models should include mammographic density.