Yoo S, et al. - A scrutiny was carried out of the predictors for the recognition of prostate cancer and clinically significant prostate cancer in the setting of repeat prostate biopsy with the aid of trans-rectal ultrasonography-guided biopsy. For the selection of subjects with a high probability for prostate cancer, trans-rectal ultrasonography before repeat prostate biopsy and the prostate-specific antigen density were discovered to be beneficial if repeat trans-rectal ultrasonography-guided biopsy was taken into account. Furthermore, these assisted in the detection of clinically significant prostate cancer.

Methods

• The enrollment consisted of 636 patients who underwent repeat prostate biopsy.
• Subjects were allocated into 2 groups according to the repeat biopsy results (with vs without prostate cancer).
• Using multivariable analysis, an inspection was conducted of the predictors for the detection of prostate cancer and clinically significant prostate cancer.

Results

• In a total of 98 patients (15.4%), prostate cancer was detected.
• No variation was noted in the prostate-specific antigen velocity.
• However, higher prostate-specific antigen density was reported in the patients with prostate cancer at the initial (0.14 vs 0.17 ng/mL/cc, p=0.049) and repeat biopsies (0.17 vs 0.26 ng/mL/cc, p < 0.001).
• As per the outcomes, the proportions of subjects who met the active surveillance criteria were as follows: 22.4% (Johns Hopkins), 30.6% (University of Toronto), 32.7% (University of California at San Francisco), 30.6% (Prostate Cancer Research International Active Surveillance), 27.6% (Memorial Sloan Kettering Cancer Center), and 13.3% (University of Miami).
• Data illustrated that age, hypoechoic lesion on trans-rectal ultrasonography, and prostate-specific antigen density at the repeat biopsy served as the prominent predictors for prostate cancer and clinically significant prostate cancer, as exhibited in the multivariable analysis.