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Predictive value of three clinical criteria for sepsis (qSOFA, SIRS, and NEWS) with respect to short-term mortality in allogeneic hematopoietic cell transplant recipients with suspected infections

Clinical Infectious Diseases Mar 11, 2020

Lind ML, Phipps AI, Mooney S, et al. - Researchers performed this study with allogeneic hematopoietic cell transplant recipients with suspected infections, to assess short-term mortality in these individuals in relation to three clinical criteria for sepsis [Systemic Inflammatory Response Syndrome (SIRS), quick-Sequential Organ Failure Assessment (qSOFA), and National Early Warning Score (NEWS)]. For patients transplanted between September 2010 - July 2017, the data from the first 100-days after transplantation were utilized. Findings revealed that the performance of NEWS was better than that of qSOFA and SIRS, but low to moderate predictive accuracy was shown by all three criteria. Experts also noted that the magnitude of the known predictive limitations of qSOFA and SIRS were at least as large as in general populations. The necessity for population-specific sepsis criteria for immunocompromised patients was indicated.
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