Childhood asthma is known as an inflammatory condition with heterogeneous consequences, this retrospective study was conducted to unveil the effect of total IgE, blood eosinophil, allergen sensitization, and inhaled corticosteroid (ICS) on longitudinal results and to determine characteristics for distinguishing different outcomes.

• Participants included 383 childhood asthma patients and another 313 patients with blood eosinophil data only receiving regular program-based visits from September 1, 2004, to December 31, 2018.

• A significant association of the percentage of blood eosinophils with increased asthma severity (OR: 1.043) was found.

• Mold sensitization was identified to be significantly linked with asthma severity (OR: 2.2485).

• The best area under the receiver operating characteristic curve value was offered by characteristics including sensitization status plus ICS dosage, for predicting longitudinal peak expiratory flow (PEF) predicted % (0.6609), PEF variability (0.6885), asthma severity (0.5918), and asthma control (0.6441), respectively.

• Overall, risk for adverse clinical results at follow-up differed between serum IgE, blood eosinophil, and allergen sensitization detected at baseline.