Tapia G, Suvitaival T, Ahonen L, et al. - Because genetic markers are known to be predictive of type 1 diabetes, but the early life environment is unknown, experts aspired to explore whether selected polar metabolites in cord blood contribute to the prediction of type 1 diabetes. They quantified 27 low molecular weight metabolites (including amino acids, small organic acids, and bile acids) in 166 children who later developed type 1 diabetes and 177 random control children in the Norwegian Mother, Father, and Child (MoBa) cohort using a targeted UHPLC-QQQ-MS platform. Aminoadipic acid, indoxyl sulfate, and tryptophan had the strongest associations for metabolites, with other aORs close to 1.0 and none significantly associated with type 1 diabetes. The authors found no evidence that cord blood concentrations of selected bile acids and other small polar metabolites predict the development of type 1 diabetes in this large study.