Soliman RM, Elsayed Y, Said RN, et al. - Whether extubation success in mechanically ventilated infants can be predicted by a lung ultrasound severity score (LUS) and evaluation of left ventricular eccentricity index of the interventricular septum (LVEI) by focused heart ultrasound, was investigated in this prospective analysis of premature infants less than 34 weeks’ of gestation. An investigator masked to infants’ ventilator parameters conducted LUS on postnatal Days 3 and 7. At postnatal Day 3, measurements of LVEI and pulmonary artery pressure (PAP) were obtained. Overall 104 studies were conducted to 66 infants; of them 39 were suffering from mild and 65 from moderate‐severe lung disease. Findings revealed that prediction of extubation success in mechanically ventilated preterm infants was enabled by LUS, with a sensitivity and a specificity of 91% and 69%, respectively, and area under the curve was 0.83. LVEI was shown to be correlated with high PAP.