This study was attempted with the aim to predict prostate cancer employing novel biomarker ratios and built a predictive scoring system. Findings demonstrate neutrophil-to-lymphocyte ratio (NLR) as a good predictor for prostate cancer and its use in this scoring system offers more disease specificity than prostate specific antigen (PSA) alone.

• From a total of 703 patients who underwent prostate biopsy, data were screened retrospectively.

• Participants (aged from 43 to 89 years) were split into 2 groups based on biopsy results; positive for prostate cancer (n = 290, 41.3%) and negative for cancer (n = 413; 58.7%).

• In the univariate analysis, age, digital rectal examination (DRE), prostate volumes, NLR, prostate specific antigen density (PSAD) were found to be the independent variables with p < 0.001.

• Researchers modelled a scoring system using NLR < 0.9, PSAD > 0.4, Age > 70 and DRE.

• Prostate cancer was shown to be predicted by a score of 2 or more, with sensitivity and specificity of 83.8% and 86.4%, respectively.