Li C, Zhou Y, Liu J, et al. - Researchers investigated the role of serum exosomes (SE) in cancer development. They performed a quantitative proteomics analysis to determine the protein content in SEs including 30 individuals from oral squamous cell carcinoma (OSCC) patients with lymph node metastasis (LNM), OSCC patients with no LNM (NLNM), and healthy controls (HC). They identified a total of 415 proteins. Comparing with HC and OSCC-NLNM, OSCC-LNM displayed 37 proteins and 28 proteins in the SEs, respectively. Findings suggest a possible correlation of PF4V1, CXCL7, F13A1, and ApoA1 from SEs with the metastasis of OSCC, which may aid in the diagnosis of OSCC-LNM.