Gunning WT, et al. - Whether postural orthostatic tachycardia syndrome (POTS) is an autoimmune disorder, as has been revealed as a possibility in a growing body of evidence, was investigated in this study, with a focus on antinuclear antibodies and the levels of ganglionic, adrenergic, and muscarinic acetylcholine receptor antibodies. Among 55 patients diagnosed with POTS, having a multitude of comorbidities, and viral-like symptoms preceding episodes of syncope, researchers examined clinical symptoms in detail and assessed serum levels of autoantibodies against 4 subtypes of G-protein coupled adrenergic receptors and 5 subtypes of G-protein coupled muscarinic acetylcholine receptors via ELISA. The study sample predominantly comprised of young females. In this study, further evidence was generated showing the presence of at least 1 elevated G-protein coupled adrenergic autoantibody in POTS patients in most cases and the presence of both adrenergic and muscarinic autoantibodies in some instances, supporting the hypothesis that POTS may be an autoimmune disorder.