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Postoperative infection predicts poor survival in locoregionally advanced oral cancer

Head & Neck Aug 09, 2019

Mascarella MA, Azzi JL, da Silva SD, et al. - Researchers examined how survival in patients with locoregionally advanced oral cavity squamous cell carcinoma (OCSCC) is influenced by postoperative infection. A retrospective study of 114 patients with stage III/IVA OCSCC undergoing curative-intent surgery was performed; of these 54 reported a postoperative infection. Outcomes revealed lower 5-year overall survival (OS) in patients with a postoperative infection (24.1%) vs those without. After adjusting for patient, antibiotic, pathologic, and operative factors, postoperative infection was identified to be a negative predictor of OS; the adjusted hazard ratio for OS was 2.54.
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