Muñoz D, Uzoije P, Reynolds C, et al. - In Alabama, researchers conducted a randomized, controlled trial—assigning adults without cardiovascular disease to a polypill group or usual-care group—in order to gather data regarding the use of polypill therapy in underserved US communities in which adherence to guideline-based care is generally low. The polypill components were atorvastatin (10 mg), amlodipine (2.5 mg), losartan (25 mg), and hydrochlorothiazide (12.5 mg). In this trial, 303 adults (96% black) were enrolled. An annual income below $15,000 was reported for three-quarters of participants. Compared with usual care, a polypill-based strategy resulted in larger decreases in systolic blood pressure and LDL cholesterol level in this socioeconomically vulnerable minority population.