Xiao H, Xu D, Mao R, et al. - Analyzing the effectiveness and safety of platelet-rich plasma (PRP) in facial rejuvenation, the existence of very limited clinical evidence was realized. To establish PRP’s efficacy in facial rejuvenation, further clinical studies are warranted. Also, a consensus for endpoints employed for establishing clinical usefulness in patients needing facial rejuvenation is warranted.

• This systematic literature review involved 36 clinical studies assessing the results following PRP-based facial rejuvenation either as monotherapy or in combination with other treatment modalities.

• Of these studies, 17 were observational and 18 were interventional with 1 being case report PRP was assessed either alone or together with hyaluronic acid, lipofilling, micro-needling technique, and laser-based interventions.

• Relative safety as well as effectiveness of enhanced platelet concentrate in a fibrin matrix was reported in one study; with a maximum benefit noted at 12 weeks implying the platelet-rich fibrin matrix could offer desired aesthetic results and it needs further studies to corroborate.