Platelet activation and clotting cascade activation by dialyzers designed for high volume online hemodiafiltration
Hemodialysis International Aug 10, 2017
Tangvoraphonkchai K, et al. – Whether or not online postdilutional hemodiafiltration (OL–HDF) increased platelet activation and extracorporeal circuit (ECC) clotting, was investigated in this study. Researchers did not notice any macroscopic clotting or increased thrombin antithrombin complexes (TATs) during OL–HDF, as well as, no major differences between cellulosic and polysulphone dialyzers were found, despite being pro–thrombotic, with activation of platelets, and lymphocytes during passage through ECC.
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