Aglago EK, Schalkwijk CG, Freisling H, et al. - This case-control study nested within a large European cohort was performed to assess colorectal cancer risk in relation to plasma levels of advanced glycation end-products (AGEs), N ^ε -(carboxy-methyl)lysine (CML), N ^ε -(carboxy-ethyl)lysine (CEL), and N ^δ -(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) , total AGEs, and [CEL+MG-H1: CML] and [CEL:MG-H1] ratios. According to findings, there seemed an inverse link of individual AGEs concentrations with colorectal cancer risk, a strong positive risk association was demonstrated by a higher ratio of methylglyoxal-derived AGEs compared with those derived from glyoxal (computed by [CEL+MG-H1: CML] ratio). Inverse colorectal cancer risk correlations were observed for CML, MG-H1, and total AGEs, though no correlation was observed for CEL. A higher [CEL+MG-H1: CML] ratio was associated with colorectal cancer risk.