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Plasma biomarkers outperform echocardiographic measurements for cardiovascular risk prediction in kidney transplant recipients: Results of the HOMe ALONE study

Clinical Kidney Journal Nov 01, 2021

Emrich IE, Scheuer AL, Rogacev KS, et al. - Plasma biomarkers can strongly and independently predict the occurrence of heart failure and atherosclerotic cardiovascular events post-kidney transplantation, whereas standard echocardiographic follow-up does not enhance cardiovascular risk prediction.

  • Kidney transplant recipients (KTRs) carry a high cardiovascular disease burden.

  • A prospective study (HOMe ALONE) of 177 KTR who were followed-up for 5.4 ± 1.7 years.

  • A consistent association of only NT-proBNP (among all echocardiographic and plasma biomarkers measured) with hospitalization for acute decompensated heart failure or all-cause death was evident (third vs first tertile: HR 4.20).

  • Only troponin T was consistently related to major atherosclerotic cardiovascular events or all-cause death (third vs first tertile: HR 8.15).

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