Planned oocyte cryopreservation—10–15-year follow-up: Return rates and cycle outcomes
Fertility and Sterility Mar 19, 2021
Blakemore JK, Grifo JA, DeVore SM, et al. - Researchers conducted a retrospective cohort study of patients who underwent at least 1 cycle of planned oocyte cryopreservation between Jan 2005 and December 2009 in order to determine the outcomes of planned oocyte cryopreservation patients most likely to have a final disposition. Included were 231 patients with 280 cycles. Till date, the oocytes of 88 patients (38.1%) have been thawed/warmed, 109 (47.2%) remain in storage, 27 (11.7%) have been discarded, and 7 (3.0%) have been transported elsewhere. The mean age at the time of thaw/warming was 43.9 years (range, 38–50) for the 88 patients who thawed/warmed oocytes, with a mean of 5.9 years frozen. On average, there were 14.3 oocytes thawed/warmed per patient, with 74.2% survival and a mean fertilization rate of 68.8% of surviving oocytes. Overall, a final outcome was obtained in 80 cases with thaw/warming embryos. Of these, 20 had nothing for ET (arrested/aneuploid), and of the 60 who had ≥ 1 ET, 27 had a total of 32 infants, with a live birth rate of 33.8% (27/80). The final outcomes of patients most likely to have returned are reported here, which may have implications for patient counseling. They observed a utilization rate of 38.1% and a no-use rate of 58.9%, which were similar across age groups.
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