Nave AH, Rackoll T, Grittner U, et al. - Researchers examined whether performing aerobic exercise is safe and efficacious in improving activities of daily living in the subacute phase after stroke. In this multicentre, randomized controlled, endpoint blinded trial, they enrolled 200 adults with subacute stroke (days 5-45 after stroke) who had a median National Institutes of Health stroke scale (NIHSS, range 0-42 points, higher values indicating more severe strokes) score of 8 (interquartile range 5-12). Participants were randomized to receive either aerobic, bodyweight supported, treadmill based physical fitness training or relaxation sessions, each for 25 minutes, five times weekly for 4 weeks, in addition to standard rehabilitation therapy. Outcomes revealed no superiority of aerobic bodyweight supported, treadmill based physical fitness training to relaxation sessions for maximal walking speed and Barthel index score among moderately to severely affected adults with subacute stroke, however, the aerobic exercise did relate with higher rates of adverse events. Results thereby do not provide support to the use of aerobic bodyweight supported fitness training in people with subacute stroke to improve activities of daily living or maximal walking speed.