Du Z, et al. - This systematic review and meta-analysis comprised exclusively of peer-reviewed articles and randomized controlled trials (RCTs) evaluated the potential cognition-related benefits of exercise in patients with Alzheimer’s disease (AD). Bibliographic databases were used to identify RCTs published in any language between January 1, 1960, and January 1, 2018, and data collected were analyzed by Review Manager (5.3). Researchers evaluated 869 patients with AD from 13 RCTs. Patients in the intervention group received pure exercise interventions and a cognitive test. Despite the observed heterogeneity in intervention methods and cognitive measures among studies, results showed that exercise intervention may help to improve the cognitive function of patients with AD or slow the decline of cognition; however, this link was not always true across studies.