Sung KC, Hong YS, Lee JY, et al. - Apparently healthy adults exhibited a positive, graded link between physical activity and the prevalence as well as the progression of coronary artery calcium (CAC), irrespective of baseline CAC scores.

• In this prospective cohort analysis of men and women free of overt cardiovascular disease, 25,485 participants with at least two CAC score measurements were included.

• Inactivity, moderate activity, and health-enhancing physically active (HEPA) was exhibited by 46.8%, 38.0% and 15.2% of the participants, respectively.

• Relative to the inactive group, moderately active and HEPA participants had adjusted 5-year average increases in CAC which were 3.20 (0.72, 5.69) and 8.16 (4.80, 11.53).

• Faster progression of CAC scores, in those with CAC=0 at baseline and in those with prevalent CAC, was evident in relation to higher physical activity.