Liew YCC, et al. - Given that solid organ transplant recipients (sOTR) are at an increased risk of developing cutaneous cancers, particularly squamous cell carcinoma (SCC), researchers assessed the role of photodynamic therapy (PDT) in the prevention and treatment of actinic keratosis (AK)/SCC in sOTRs. Articles were selected to report PDT results between sOTRs with or without baseline AK/SCC. Of the 641 articles, 12 met the criteria for eligibility, out of which 4 RCTs reported the preventive effect of AK/SCC and 5 RCTs reported the treatment effect of PDT in sOTR. In the treatment group, the CR in PDT was higher with a pooled RD of 0.77 and 0.50 respectively in pre-divided lesional areas and number of lesions. The authors concluded that PDT is effective in preventing and treating AK/SCC in sOTRs.