Darkovska-Serafimovska M, et al. - Authors attempted to appraise the efficacy of cannabis preparations for relieving pain in patients with malignant diseases by comparing cannabis preparation to placebo. About 10 actuations per day, which was about 27 mg tetrahydrocannabinol (THC) and 25 mg cannabidiol (CBD), was demonstrated to be the most likely target dose for relieving pain in patients with malignant diseases. Findings recommended that the highest approved recommended dose was 12 actuations per day (32 mg THC/30 mg CBD). Drowsiness, nausea, vomiting and dry mouth were the key side effects.