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Personalized prediction of overall survival in patients with AML in non-complete remission undergoing allo-HCT

Cancer Medicine Jun 20, 2021

Hirabayashi S, Uozumi R, Kondo T, et al. - Researchers sought to construct as well as validate nomograms and a web application for the prediction of overall survival of patients with non-complete remission acute myeloid leukemia receiving allogenic hematopoietic stem cell transplantation (allo-HCT) (cord blood transplantation [CBT], bone marrow transplantation [BMT], and peripheral blood stem cell transplantation [PBSCT]). They analyzed data from 3,052 patients. They found age, performance status, percentage of peripheral blasts, cytogenetic risk, chemotherapy response, and number of transplantations, were common significant prognostic factors in patients receiving allo-HCT. The lowest hazard ratio for mortality was reported for a conditioning regimen of ≥3 drugs, including fludarabine, with CBT vs cyclophosphamide/total body irradiation. Herein, prognostic models were built on the basis of outcomes of the multivariable analysis, and these models not only demonstrated adequate calibration and discrimination (the c-indices for CBT, BMT, and PBSCT were 0.648, 0.600, and 0.658, respectively) but are also capable of assisting in evaluation of individual risks and in designing future clinical studies. Findings also indicate that multi-drug conditioning regimens are effective in patients receiving CBT.

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