Sestan M, Srsen S, Kifer N, et al. - Researchers conducted this national multicenter retrospective study to assess the prevalence and severity of skin involvement in children with IgA vasculitis (IgAV) and its association with clinical and biochemical parameters and the risk of developing IgA vasculitis nephritis (IgAVN), the only cause of long-term morbidity and the main prognostic factor in IgAV patients. Between 2009 and 2019, 611 patients under the age of 18 with IgAV were referred to five Croatian tertiary hospitals. Patient information was gathered from a database through a systematic analysis of IgAV patients in the Croatian population. According to multivariate logistic regression, the presence of ulcerations and necroses, persistent purpura, and higher age were significant predictors of IgAVN, while persistent purpura, male sex, and higher age were predictors of persistent IgAVN. Higher serum urea and a decrease in activated partial thromboplastin time were found to have a significant impact on the risk of persistent IgAVN among laboratory parameters. With increasing severity and duration of cutaneous manifestations in IgAV, the risk of developing IgAVN rises, worsening the prognosis and necessitating more aggressive treatment.