Farladansky E, Hazan S, Maman E, et al. - In this randomized trial, the analgesic effects of pregabalin vs single-shot interscalene brachial plexus block (ISBPB) were assessed in adults having arthroscopic rotator cuff (RC) repair. In addition, researchers investigated ISBPB’s effect on postoperative opioid consumption, patient satisfaction, and opioid-related adverse effects. They performed randomization of 79 adults having arthroscopic RC repair to receive perioperative oral pregabalin (Lyrica, twice daily starting the evening before surgery, for a total of 4 doses) or single-shot ISBPB (20 ml of bupivacaine 0.25%). Outcomes revealed comparable analgesic effects of perioperative use of pregabalin to that of ISBPB for 10 days after surgery among adults undergoing arthroscopic RC repair.