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Perinatal risk factors associated with central retinal changes in former preterm children on optical coherence tomography angiography

Acta Ophthalmologica May 06, 2021

Lavric A, Markelj S, Ding J, et al. - In this prospective cohort study, researchers intended to determine if there is an association between perinatal risk factors for retinopathy of prematurity (ROP) and central retinal structures of former preterm children seen on optical coherence tomography angiography (OCTA). The sample consisted of 40 children with a history of preterm birth and 33 healthy full‐term children. Their birth weight, gestational age, other significant risk factors for ROP development, and the presence of ROP were all documented. Analytic parameters involved the area of foveal avascular zone (FAZ), foveal depth (FD), central subfoveal retinal thickness (CSFT) and capillary density index (CDI) of the deep and superficial capillary plexus. When compared with controls, preterm children had significantly smaller FAZ, lower FD and higher CSFT. Both groups showed no variationsin total CDI at the superficial and deep capillary plexus. The duration of mechanical ventilation and the presence of bronchopulmonary dysplasia were found to be associated with lower FD and higher CSFT in a regression analysis. OCTA was used to detect central retinal anomalies in former preterm children. Macular changes were linked to several risk factors for ROP development.

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