Baguiya A, Bonet M, Cecatti JG, et al. - One-third of all births had a negative perinatal outcome. The primary risk factors for adverse perinatal outcomes were pre-existing maternal medical conditions and severe infection-related maternal outcomes.

• The research was performed in 408 hospitals in 43 LMIC of all the WHO regions in 2017.

• One thousand two hundred nineteen births were analyzed.

• Data reported that 25.9% (n = 316) and 10.1% (n = 123) were neonatal near-miss (NNM) and perinatal deaths, respectively.

• Maternal pre-existing medical condition and maternal infection suspected or diagnosed during labour remained independent risk factors for NNM after adjustment.

• Pre-existing maternal medical condition, infection-related severe maternal outcome, mother's infection suspected or diagnosed within 24 hours after childbirth, and vaginal birth were all independently associated with an elevated risk of perinatal death.