Ilg A, et al. - Given the utility of the clinical prediction rule CURB-65 (comprised of confusion, uremia, elevated respiratory rate, hypotension, and age 65 years or older) in stratifying patients with pneumonia by expected mortality, CURB-65 was examined for its prognostic value for the proximal endpoint of receipt of critical care intervention (ie, vasopressors, large-volume intravenous fluids, invasive catheters, assisted ventilation, insulin infusions, or renal replacement therapy) in emergency department (ED) patients admitted with community-acquired pneumonia. Findings suggest that patients with CURB-65 score ≤ 2 were often admitted to the ICU and got critical care interventions. This finding, along with the relatively low sensitivity of CURB-65 for critical care intervention, led researchers to recommend that clinicians practice caution while using CURB-65 to guide disposition. Future ED-based clinical prediction rules may benefit from calibration to proximal endpoints.