Qiao H, et al. - This study was performed to test the presumed usefulness of the combination of dexmedetomidine and ketamine as a premedication to alleviate preoperative anxiety and improve cooperation during intravenous cannulation in pediatric patients while producing minimal adverse events. Findings demonstrated that satisfactory separation from parents and more successful venous cannulation were achieved as a result of premedicating children scheduled for eye surgery with intranasal dexmedetomidine 2 μg/kg in combination with oral ketamine 3 mg/kg. This combo allowed children to smoothly accept induction of general anesthesia.