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Peak post-transplant lung function in bilateral lung transplant recipients using a prediction model based on donor and recipient demographic characteristics

Respiratory Medicine Jul 12, 2019

Azar M, et al. - In this single center retrospective analysis, researchers intended to design a prediction model of peak pulmonary function testing post-transplant based on donor and recipient demographic features. Patients who underwent bilateral lung transplantation between 2011 and 2015 without allograft dysfunction in the first year, were analyzed (146 donor/recipient patients). They found peak post-transplant FEV1 (forced expiratory volume in the first second) was attained in 64.30 ± 48.96 weeks and forced vital capacity was reached in 78.14 ± 50.68 weeks. Restrictive lung disease recipients had spirometry values peaked earlier. Findings revealed a significant association of higher peak FEV1 with younger donor age, non-African American donor race, male recipient sex, greater recipient height, underlying obstructive lung disease. Also, greater absolute differences between donor predicted and observed FEV1 were found to be significantly related to male donor sex, greater donor height, non-African-American donor race, female recipient sex, greater recipient height. Findings revealed the utility of donor and recipient features in predicting lung function after transplantation. The attainment of peak lung function may take greater than one year in patients without complications in the first year post-transplant.
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