Zhan M, et al. – Nonsteroidal anti–inflammatory drug use patterns and their association with other analgesic use in chronic kidney disease (CKD) have been investigated. This study highlights the common use of nonsteroidal anti–inflammatory drug among patients with CKD. However, it is less common among those with worse kidney function or those who see a nephrologist. Moreover, initiation or discontinuation of nonsteroidal anti-inflammatory drugs is often associated with supplementation with or replacement by, respectively, other analgesics, including opioids, which introduces possible drug-related problems when taking these alternative analgesics.