Mokhtarzadeh H, et al. - A cross‐sectional study in a sample of adult men and women from a population‐based cohort was performed to ascertain which activities cause the largest vertebral load‐to‐strength ratio (LSRs) and evaluate patterns of LSRs along the spine for these high‐load activities. Researchers applied subject‐specific musculoskeletal models of the trunk to ascertain vertebral compressive loads for 109 activities in 250 individuals (aged 41 to 90 years, 50% women) from the Framingham Heart Study. These outcomes serve as the first guidance on what activities to consider when assessing vertebral load‐to‐strength ratios in future studies, including those analyzing dynamic motions and the biomechanics of vertebral fractures.