Patterns of antibody response to SARS-CoV-2 among 1.6 million blood don

The Journal of Infectious Diseases Oct 14, 2021

Dodd RY, Notari EP, Brodsky JP, et al. - Antibodies to SARS-CoV-2 S1 protein were tested in 1,654,487 blood donors from December 2020 to June 2021.

Reactivity was observed in 1,028,547 blood donors (62.17%).
Vaccination had resulted in the rapid increase in prevalence.
Among a subset of 1,567,446 donors, SARS-CoV-2 vaccination was reported in 729,771 (46.56%), of whom 633,769 (86.84%) were S1-antibody reactive only, in response to vaccination and 68,269 (9.35%) were reactive to both S1 and nucleocapsid, in response to prior infection; no reactivity was evident to either antibody in the remainder.
Vaccination was not reported in 837,675 (53.44%) donors; of these, 210,022 (25.07%) showed reactivity to both antibodies and 29,446 (3.52%) to S1 only.

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