Schoos M, et al. - In a multicenter study of 5,018 patients who underwent percutaneous coronary intervention (PCI), researchers analyzed the patterns as well as clinical influence of different modes of dual-antiplatelet therapy (DAPT) cessation following PCI in patients presenting with and without acute coronary syndromes (ACS). The different categories of DAPT cessation included physician-recommended discontinuation, interruption, or disruption. Between non-ACS and ACS patients, no difference was seen in overall rates of 2-year DAPT discontinuation (38.8% vs 37.2%). Findings revealed that the incidence of DAPT cessation mode was different based on presentation with or without ACS. The most common mode of DAPT cessation was physician guided DAPT discontinuation and this mode appeared to be safe across both groups. The interruption of DAPT in ACS patients was found to be related to higher rates of adverse events.