Thurmaier J, Heinemann V, Engel J, et al. - Among patients suffering from colorectal cancer (CRC) and brain metastasis (BM), this inquiry was performed to determine the predictive influence of extracranial metastatic patterns on course of disease as well as survival. Overall 228 patients (134 men [59%], 94 women [41%]) with histologically confirmed CRC and BM were included. Liver (102 of 228 [44.7%]) and lung (96 of 228 [42.1%]) were the extracranial organs that were mostly affected. Computed over the whole course of disease, longer overall survival (OS) was revealed in patients with lung metastasis vs patients with liver metastasis or patients without lung metastasis. OS from the diagnosis of liver metastasis was noted to be longer vs from lung metastasis. In all survival categories examined, shortest survival times revealed patients with concurrent liver and lung metastasis. Overall, experts concluded that a heterogeneous cohort was formed by patients with CRC and BM, in which survival was predicted by extracranial metastasis to liver or lungs.