Thurmaier J, Heinemann V, Engel J, et al. - Researchers sought to determine the predictive effect of extracranial metastatic patterns on the course of disease as well as survival among patients experiencing colorectal cancer (CRC) and brain metastasis (BM). Computed over the whole course of disease, a longer OS was reported in patients with lung metastasis vs those experiencing liver metastasis or those without lung metastasis. From the date of initial CRC diagnosis, lung metastasis developed later in CRC history compared with liver metastasis. A longer survival was experienced by patients with lung metastasis than those with liver metastasis, once BM was present. In all survival categories examined, patients with concurrent liver and lung metastasis were revealed by shortest survival times. As concluded, a heterogenous cohort where survival is predicted by EM to liver or lung is formed by patients with CRC and BM.