Patients with bullous pemphigoid and comorbid psoriasis present with less blisters and lower serum levels of anti‐BP180 autoantibodies
Journal of the European Academy of Dermatology and Venereology Oct 28, 2020
Ständer S, Schmidt E, Zillikens D, et al. - Researchers conducted this retrospective cohort study to estimate the prevalence of psoriasis among patients with bullous pemphigoid (BP) and to illustrate the clinical and immunological features of BP patients with comorbid psoriasis. The sample consisted of all consecutive patients diagnosed with BP throughout the years 2009‐2019 in a tertiary referral center. Participants in the study were 273 patients with BP, 11 of whom had comorbid psoriasis. Patients with BP and comorbid psoriasis were significantly younger at the onset of BP compared with BP patients without psoriasis, had a milder erosive phenotype, lower levels of anti‐BP180 NC16A serum autoantibodies as well as a higher prevalence of isolated linear C3 deposits and a lower prevalence of linear immunoglobulin G deposits along the dermal‐epidermal junction by direct immunofluorescence microscopy. A milder erosive phenotype and lower levels of pathogenic autoantibodies are present in patients with BP and comorbid psoriasis at a younger age.
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