Madsen MB, Skrede S, Perner A, et al. - Researchers assessed patient’s features as well as links between baseline variables and microbiological findings, amputation, and 90-day mortality among adults with necrotizing soft-tissue infections (NSTI) in this international, multicenter, prospective cohort study. Overall, 409 patients with NSTI, of which, 402 admitted to the ICU, were included. The most common comorbidities were cardiovascular disease. Skin bruising prior to surgery was common. Abdomen/ano-genital area and lower extremities were affected in most of the cases. A common occurrence of septic shock and acute kidney injury was documented. The all-cause 90-day mortality was estimated to be 18%. Findings revealed heterogeneity among NSTI patients as far as comorbidities, initial symptoms, infectious localization, and microbiological findings were concerned. Increased mortality was observed in correlation with higher age and lactate levels. Decreased mortality was reported in relation to group A streptococcus infection.