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Patient global assessment and radiographic progression in early arthritis: 3‐year results from the ESPOIR cohort

Arthritis Care & Research May 03, 2020

Ferreira RJO, Fautrel B, Saraux A, et al. - This study was attempted to ascertain whether patient global assessment (PGA), as part of Boolean‐based definition of remission and individually considered, over the first year of disease course had a significant relationship with structural progression over 3 years in patients with early arthritis (EA). ESPOIR cohort data was applied to conduct prospective, observational study to characterize remission states as (a) 4v‐remission: tender, swollen 28‐joint counts, C‐Reactive protein (mg/dL), and PGA (0‐10) all ≤ 1; (b) PGA‐near‐remission: same parameters with only PGA>1/10; (c) 3v‐remission (sum of previous groups) or (d) non‐remission. Researchers ascertained radiographic progression as a change in total Sharp‐van der Heijde score from baseline to 3 years (ΔSHS) ≥5 points. They evaluated predictive capacities for radiographic damage of different remission definitions by Odds Ratio (OR). They evaluated correlation between each individual component of remission with ΔSHS through multivariate linear regression analyses. A total of 520 patients were included in the study. All definitions of remission led to low structural degradation in EA: compared with PGA‐near‐remission, 4v‐remission led to less progression but without a statistically significant difference. It was noted that both 4v‐remission and 3v‐remission seem beneficial targets when aiming at structural non‐progression.

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