Larach DB, Sahara MJ, As-Sanie S, et al. - Via this single-center prospective observational cohort study, preoperative patient characteristics that are linked with postoperative outpatient opioid use are investigated and the frequency of postoperative opioid overprescribing was determined. They included 1,181 opioid-naïve patients undergoing hysterectomy, thoracic surgery, and total knee and hip arthroplasty. Of these, 1,001 had complete primary outcome data and 913 had complete phenotype data. Increased opioid consumption was observed in significant correlation with younger age, non-white race, lack of a college degree, higher anxiety, greater sleep disturbance, heavy alcohol use, current tobacco use, and larger initial opioid prescription size. Median total oral morphine equivalents prescribed and median opioid consumption were 600 mg (equivalent to one hundred twenty 5-mg hydrocodone pills) and 188 mg (38 pills), respectively.