Bryce C, Grimes Z, Pujadas E, et al. - In this study, the first 100 COVID-19-positive autopsies performed at the Mount Sinai Hospital in New York City are reported. Autopsies revealed large pulmonary emboli in six cases and diffuse alveolar damage in over 90% of cases. In addition, microthrombi in multiple organ systems including the brain, as well as hemophagocytosis, were described. Further, electron microscopic evidence of the presence of the virus in the samples was provided. Elevated inflammatory markers, abnormal coagulation values, and elevated cytokines IL-6, IL-8, and TNFα were evident in this COVID-19 cohort as per laboratory results. Based on findings from this autopsy series of COVID-19-positive patients, they suggest that this disease has widespread effects in the body including hypercoagulability, a hyperinflammatory state, and endothelial dysfunction. These multisystemic pathways, if targeted, could result in new therapeutic avenues as well as combination therapies against SARS-CoV-2 infection.