Ware MA, Kaar JL, Behn CD, et al. - Adolescents with polycystic ovary syndrome (PCOS) and obesity may exhibit insulin resistance, dysglycemia, and hepatic steatosis. In view of the possibility that excess pancreatic fat may lead to a disturbance in insulin secretion and relate to hepatic fat, researchers sought to determine the correlations between pancreatic fat fraction (PFF) and metabolic measures in PCOS.

• A total of 113 sedentary, nondiabetic adolescent girls (age = 15.4 [1.9] years), with or without PCOS and BMI ≥ 90th percentile were assessed in this secondary analysis.

• Individuals with PCOS showed elevated visceral fat and hepatic fat fraction (HFF) when compared with control individuals, but there was similar PFF.

• Findings suggest no correlation of either PCOS status or androgens with PFF.

• However, higher PFF linked with worse fasting insulin and postprandial lipids.