Petrick JL, et al. - Given that esophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) are among the most rapidly increasing cancer types in Western countries, researchers evaluated weight change between childhood and early adulthood in relation to EA/GCA. For 64,695 young men from the Copenhagen School Health Records Register and the Danish Conscription Database, measured weights and heights during childhood (7-13 years) and early adulthood (17-26 years) were available. Investigators found that EA/GCA risk was 2.5 times higher in men who were first classified as being overweight at age 7 vs men who were never classified as being overweight. Men with persistent overweight at 7 and 13 years of age and early adulthood had a 3.2-fold higher risk of EA/GCA. However, there was little evidence of increased risk of EA/GCA during childhood for men with overweight and subsequent early adult remittance. Persistent early-life overweight was thus associated with increased risk of EA/GCA, which reduces when body weight decreases.