Oguz A, Sahin M, Ulgen C, et al. - Diabetic males frequently develop hypogonadism and a crucial contributing factor of it could be poor glycemic control. In addition, overt hypogonadism is an essential cardiovascular risk marker. Thus, in diabetic patients, both glycemic control and complications may be positively impacted by ensuring eugonadism.

• This analysis involved 261 non-obese males with type 2 diabetes aged 18–70; hypononadal males (38.7%) included overt hypogonadism and borderline hypogonadism and controls were eugonadal diabetic males (61.3%).

• A significantly higher macrovascular complication rate was seen in hypogonadal males, with no difference in microvascular complication rate.

• Hypogonadal patients had significantly lower optimal glycosylated hemoglobin achievement(<7%).

• Independent risk factors for macrovascular complications included overt hypogonadism, hypertension, hypercholesterolemia and severe hypoglycemia, with ORs 1.0, 2.6, 1.8, and 1.0, respectively.

• Independent risk factors for microvascular complication were: diabetes duration (≥5 years) and poor glycemic control, with OR 1.0 and 2.0, respectively.