Hamidi O, et al. - In patients with benign large thyroid nodules (TNs) treated at Mayo Clinic, authors contemplated the effectiveness, tolerability and complications of radiofrequency ablation (RFA). Data displayed a substantial volume reduction of predominantly solid TNs, improvement in the compressive symptoms and cosmetic concerns via RFA of benign large TNs. It did not affect normal thyroid function. Findings revealed that RFA had an acceptable safety profile and ought to be taken into account as a low-risk alternative to conventional treatment of symptomatic benign TNs.