Mattos BRS, Camandaroba MPG, Ruiz-Garcia E, et al. - This research sought to correlate the clinical outcomes of metastatic squamous cell carcinoma of the anal canal (mSCCA) patients according to HIV infection. Researchers conducted a retrospective multicenter cohort study of consecutive patients with mSCCA. Antiretroviral therapy administered to all HIV-positive patients. The primary outcome included overall survival and progression-free survival and response rate were considered as secondary outcomes. In this study, 113 patients were enrolled: 20 (17.6%) had HIV infection between January 2005 and December 2019. This study’s findings demonstrate that HIV-positive mSCCA patients under antiretroviral therapy have similar oncological outcomes to HIV-negative patients. These individuals should be enrolled in trials of mSCCA.