Lee H, et al. - In this retrospective review, researchers assessed the prognosis of patients with renal cell carcinoma (RCC) who were up-staged from clinical stage T1 to pathologic stage T3a, using Kaplan-Meier and Cox proportional analyses. Patient age, tumor diameter, and hilar location were found to be significantly related to upstaging. shorter survival outcomes were demonstrated by patients up-staged from clinical stage T1 to pathologic stage T3a RCC, relative to those without upstaging. In multivariate Cox analyses, pathologic upstaging was identified as an independent predictor of shorter recurrence-free, cancer-specific, and overall survivals. However, in patients who were up-staged, comparable outcomes of partial nephrectomy vs radical nephrectomy were seen.