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Outcomes of multi-organ transplant in adult patients with congenital heart disease

Journal of the American Heart Association Nov 23, 2019

Wong K, et al. - Researchers assessed 5-year results in adult congenital heart disease (ACHD) patients (aged ≥ 18 years) who had dual organ (heart+kidney/liver/lung) transplantation between 2000 and 2016, by using the SRTR (Scientific Registry of Transplant Recipients) database. They developed Cox proportional hazards models to determine the survival of dual organ transplant recipients vs heart-only recipients in the ACHD population and heart+lung recipients vs heart-only recipients in the ACHD populations and vs non-ACHD recipients of heart+lung transplant. Findings revealed that heart+lung transplants primarily accounted for the observed mortality risk related to multiorgan heart transplant in ACHD patients. No increased risk was reported in relation to multiorgan transplant in ACHD vs the non-ACHD population. Heart+lung transplant, prior cardiac surgery, and severe functional limitation were identified as factors that conferred risk for increased risk of 5-year mortality in ACHD patients following multiorgan transplant. Listing ACHD patients requiring a heart transplant should not be hindered by the need for multiorgan transplant.
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